(R,R)-Jacobsen’s catalyst

(R,R)-Jacobsen’s catalyst

Chiral Catalysts, Ligands, Reagents, Kinetic Resolution, Privileged Ligands and Complexes, Asymmetric Synthesis, Chemical Synthesis, Chiral Catalysts, SALENs, Fluorination Catalysts and Ligands, Synthetic Reagents, Fluorination Reagents

Applications

1) (R,R)-Jacobsen’s catalyst is used for efficiently producing pharmaceutically important, single enantiomer amino alcohols from the corresponding chiral epoxide by acid or base-catalyzed epoxide ring-opening reactions (Ref: Encyclopedia of Reagents for Organic Synthesis, 1995, 7, 4585.)

2) (R,R)-Jacobsen’s catalyst is used for:

A) Conversion of olefins to chiral epoxides in high enantiomeric excess (J. Org. Chem., 1993, 58, 6939; J. Am. Chem. Soc., 1994, 116, 6937)

B) Asymmetric Kinetic resolution of secondary alcohols in water (Angew. Chem. Int. Ed. Eng., 2003, 42, 1042)

C) Enantioselective Reformatsky reaction with ketones (Angew. Chem. Int. Ed. Eng., 2006, 45, 2951)

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